Abstract
BACH and Williamson1 claim to have shown that rat liver forms urea from ammonium lactate even when the activity of arginase is inhibited by high concentrations of ornithine2. They conclude that liver can synthesize urea without the participation of arginase.
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Bach, S. J., and Williamson, S., NATURE, 150, 575 (1942).
This inhibition was first observed by R. E. Gross (Z. physiol. Chem., 112, 236; 1920). L. Hellerman and C. C. Stock (J. Biol. Chem., 125, 771; 1938) suggest that it may be due to the formation of metallic complexes of ornithine.
The activities vary somewhat with sex, age and other factors, but are always of the same order of magnitude (see E. Baldwin, Biol. Rev., 11, 247; 1936; H. D. Lightbody, J. Biol. Chem., 124, 169; 1938).
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KREBS, H. Urea Synthesis in Mammalian Liver. Nature 151, 23 (1943). https://doi.org/10.1038/151023a0
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DOI: https://doi.org/10.1038/151023a0
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