Abstract
PREVIOUS papers from these laboratories have shown that the subjection of yeast, other micro-–rganisms, and several animal tissues to various forms of injury, such as ultra–violet irradiation, X–rays, mechanical injury, chemical irritation and oxygen lack, results in the release into the intercellular fluids of substances which stimulate cellular proliferation. Because of the mode of formation these substances have been spoken of as “intercellular wound hormones”1.
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See for example: Fardon et al., NATURE, 139, 589 (1937); Studies Institutum Divi Thomce, 2, 39 (1938) and 2, 233 (1939); Loof-Bourow et al., NATURE, 142, 573 (1938); 143, 725 and 144, 553 (1939); Studies Inst. Divi ThomÅ", 2, 137 (1938); 2, 155 (1939): Arch, exptl. Zellforsch., 22, 607 (1939); Biochem. J., 34, 432 (1940) and 35, 603 (1941); Cook et al., Atti X° congr. intern, chim., 5, 26 (1939); Biochem. J., 34, 1580 (1940).
We are greatly indebted to Dr. Florence Meier Chase of the Smithsonian Institution, Washington, D.C., for the algal cultures.
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GIERSCH, C., COOK, E. Production of Proliferation–promoting Factors by the Ultra–violet Irradiation of Algæ. Nature 148, 754 (1941). https://doi.org/10.1038/148754b0
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DOI: https://doi.org/10.1038/148754b0
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