Abstract
IN an earlier publication1 the formula of the highly active synthetic œstrogenic analogue, stilbœstrol, was contrasted with those of œstrone and chrysene. The figures in this earlier letter in NATURE indicated that by ring closure in the case of stilbœstrol a condensed carbon ring compound similar to œstrone on one hand and to chrysene on the other could be obtained. Since all the known carcinogenic hydrocarbons possess the condensed carbon ring structure, it was decided, by analogy with œstrone, to see if it were possible to break down the condensed ring structure of the carcinogenic hydrocarbons without losing all carcinogenic activity.
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Dodds, E. C., Golberg, L., Lawson, W., and Robinson, R., NATURE, 141, 247 (1938).
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DODDS, E., LAWSON, W. & WILLIAMS, P. Carcinogenic Agent without the Condensed Carbon Ring Structure. Nature 148, 142 (1941). https://doi.org/10.1038/148142a0
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DOI: https://doi.org/10.1038/148142a0
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