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Correlation of Basicity and Antiseptic Action in an Acridine Series

Nature volume 147, pages 332–333 (1941)Cite this article

Abstract

THE amino acridines are unique among antiseptics in combining a high bacteriostatic activity in the presence of tissue fluids with a relative innocuousness to leucocytes. Hence any information that relates their physical and chemical properties with their antibacterial action is of general interest. The effect on bacteriostatic activity of varying the positions of amino groups in the acridine nucleus has already been studied in a series of diaminoacridines1 which included the widely used antiseptics proflavine (2: 8-diaminoacridine) and acriflavine. The contribution of each amino group towards the total effect was therein assessed, thus virtually predicting the antiseptic properties of the five isomeric mono-aminoacridines.

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References

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Sydney,

    ADRIEN ALBERT

  2. Department of Bacteriology, University of Melbourne,

    SYDNEY D. RUBBO

  3. Department of Agriculture, State of New South Wales,

    REGINALD GOLDACRE

Authors
  1. ADRIEN ALBERT
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  2. SYDNEY D. RUBBO
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  3. REGINALD GOLDACRE
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ALBERT, A., RUBBO, S. & GOLDACRE, R. Correlation of Basicity and Antiseptic Action in an Acridine Series. Nature 147, 332–333 (1941). https://doi.org/10.1038/147332a0

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  • DOI: https://doi.org/10.1038/147332a0

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