Abstract
PHENYL ureido derivatives of serum albumin peptone1, plastein2, and native proteins3, have been prepared by treatment with phenyl isocyanate. This reaction is eminently suitable for masking the free amino groups of protein molecules without doing further damage, since the reaction conditions are very mild (0° C. and pH 8). Hopkins and Wormall3 concluded that phenyl isocyanate reacts only with the free amino groups of the lysine components of the protein molecules.
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BOTTOMLEY, A., FOLLEY, S. Inactivation of Prolactin by Treatment with Phenyl Isocyanate. Nature 145, 304 (1940). https://doi.org/10.1038/145304b0
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DOI: https://doi.org/10.1038/145304b0
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