Abstract
DURING recent years, Fuchs's reaction has been widely applied for the diagnostics of malignant tumours. Fuchs1 has found that normal serum is able to decompose the fibrin prepared from carcinomatic blood; on the other hand, serum from a patient suffering from a malignant tumour decomposes the fibrin obtained from the blood of a normal individual. He proved the proteolysis by the increase of the non-protein nitrogen—a method proposed already by Abderhalden2—or by determining the ratio of carboxylic and amino-groups before and after the proteolysis.
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References
Fuchs, H. J., Biochem. Z., 170, 76; 175, 180; 176, 32 (1926); 178, 155 (1927).
Abderhalden, E., "Abwehrfermente" (Berlin, 1922); "Handbuch d. biol. Arbeitsmethoden" (Berlin, 1932).
Brdika, R., Collection, 5, 112 (1933); J. chim. Phps., 35, 89 (1938); Acta, Unio Internationalis contra cancrum, 3, 13 (1938). Heyrovský, J., NATURE, 142, 317 (1938).
Brdika, R., and Klumpar, J., ÄŒas sl. Lékárnictva, 17, 234 (1937).
Chrometzka, F., and Gottlebe, P., Z. exptl. Med., 86, 436 (1933).
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KOTLJAR, A., PODROUŽEK, V. Polarographic Proof of Proteolysis in Diagnosis with Enzyme Reaction. Nature 142, 872–873 (1938). https://doi.org/10.1038/142872b0
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DOI: https://doi.org/10.1038/142872b0
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