Abstract
London
Royal Society, February 25.
JULIA BELL and J. B. S. HALDANE: The linkage between the genes for colour-blindness and haemophilia in man. Colour-blindness and hsemophilia are known to be sex-linked. The genes responsible for them should therefore be carried in the same chromosome, and exhibit partial linkage with one another. Six pedigrees are described in which both conditions are found. In three of these, the genes are located in the same chromosome, and are associated throughout the pedigree, all hsemophilics investigated being also colour-blind, and none of their non-hsemophilic brothers being colour-blind. In two pedigrees, the opposite condition holds, whilst one is doubtful, including two colour-blind brothers only one of whom is heemophilic. This fact is attributed to crossing-over. A function P (x, p) of the frequency x of crossing-over, and the frequency p of colour-blindness in the male population, is calculated, which represents the probability of the observed association. The probability that the association attributed to linkage is due to sampling is less than 4 x 10˜6. The frequency of crossing-over is as likely to be above as below 5 per cent. Further confirmation has been obtained for the view that haemophilia originates by mutation.
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Societies and Academies. Nature 139, 426–427 (1937). https://doi.org/10.1038/139426b0
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DOI: https://doi.org/10.1038/139426b0