Abstract
EXPERIMENTS are being done on the effects of methylcholanthrene on mouse fibroblasts cultivated in vitro. The tissue is grown by the hanging drop method in a medium containing approximately 0·005 mgm. of the hydrocarbon per c.c. and is sub-cultivated every 48 hours. After three days' growth, the cultures when fixed in Navashin's fluid and stained with iodine-gentian-violet are found to contain a high percentage of abnormal mitotic figures of various types.
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HEARNE, E. Induced Chiasma Formation in Somatic Cells by a Carcinogenic Hydrocarbon. Nature 138, 291 (1936). https://doi.org/10.1038/138291c0
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DOI: https://doi.org/10.1038/138291c0
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