Abstract
THE view that vitamin C is identical with methylnornarcotine has been advanced by Rygh1,2, who claims that narcotine occurs in unripe fruit and disappears with corresponding formation of vitamin C during ripening. According to Rygh, guinea-pigs receiving a scurvy-producing basal diet together with a suitable daily supplement of synthetic methylnornarcotine lose weight and die but without any of the typical symptoms of scurvy. Other workers3,4,5,6 have been unable to confirm this observation or to find narcotine in unripe fruit, and Dalmer and Moll5 have shown that methylnornarcotine as prepared by Rygh is not a single chemical substance.
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References
Rygh and Rygh, Z. physiol. Chem., 204, 114.
Rygh, Rygh and Laland, Z. physiol. Chem., 204, 105.
Smith and Zilva, Chem. Ind., 51, 166.
Grant, Smith and Zilva, Biochem. J., 26, 1628.
Dalmer and Moll, Z. physiol. Chem., 209, 211.
Dann, Forsyth, Harris, Mills and Innes, Lancet, 2, 237; 1932.
Rygh and Rygh, Z. physiol. Chem., 211, 275.
Moore and Ray, NATURE, 130, 997, Dec. 31, 1932.
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DANN, W. Methylnornarcotine, Glycuronic Acid, and Vitamin C. Nature 131, 24–25 (1933). https://doi.org/10.1038/131024c0
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DOI: https://doi.org/10.1038/131024c0
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