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For IRES trans-acting factors, it is all about location

Oncogene volume 27, pages 1033–1035 (2008)Cite this article

Abstract

The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites (IRESs) present within the 5′-untranslated regions (5′-UTRs) of their messenger RNA molecules (mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.

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Authors and Affiliations

  1. Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada

    S M Lewis & M Holcik

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  1. S M Lewis
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  2. M Holcik
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Correspondence to M Holcik.

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Lewis, S., Holcik, M. For IRES trans-acting factors, it is all about location. Oncogene 27, 1033–1035 (2008). https://doi.org/10.1038/sj.onc.1210777

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