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Poly(ADP-ribose): a co-regulator of DNA methylation?

Oncogene volume 24, pages 11–12 (2005)Cite this article

Abstract

The formation of multiprotein complexes is l’ordre du jour in regulatory pathways. In this issue of Oncogene, Reale et al. report the formation of a particularly sophisticated complex of two important regulatory enzymes, DNMT1 (DNA methyltransferase-1) and PARP-1 (poly(ADP-ribose)polymerase-1). The former evolved with a specific sequence motif binding the enzymatic product of the latter. The product, poly(ADP-ribose), bonds the two partners into a heterodimeric complex and, as a consequence, the catalytic function of DNMT1 is silenced. Thus, PARP-1 becomes a conditional negative regulator of DNMT1. In a larger perspective, Reale et al. highlight the potential role of PARP-1 as a co-regulator of DNA methylation leading to epigenetic reprogramming of cancer cells.

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  1. Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland

    Felix R Althaus

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  1. Felix R Althaus
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Correspondence to Felix R Althaus.

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Althaus, F. Poly(ADP-ribose): a co-regulator of DNA methylation?. Oncogene 24, 11–12 (2005). https://doi.org/10.1038/sj.onc.1208382

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