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| Open AccessModelling post-implantation human development to yolk sac blood emergence
A genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis captures the codevelopment of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early haematopoiesis, with potential for drug testing and disease modelling.
- Joshua Hislop
- , Qi Song
- & Mo R. Ebrahimkhani
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Article
| Open AccessProgramming multicellular assembly with synthetic cell adhesion molecules
Synthetic cell adhesion molecules yield customized cell–cell interactions with adhesion properties that are similar to native interactions, and offer abilities for cell and tissue engineering and for systematically studying multicellular organization.
- Adam J. Stevens
- , Andrew R. Harris
- & Wendell A. Lim
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Article |
Human neural tube morphogenesis in vitro by geometric constraints
Stem cells cultured in a micropattern-constrained platform form a quantitative and robust model of human neural tube morphogenesis.
- Eyal Karzbrun
- , Aimal H. Khankhel
- & Sebastian J. Streichan
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Letter |
Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
Juxtaposition of region-specific gut spheroids derived from human pluripotent stem cells in the absence of extrinsic factors results in development of segregated hepato-biliary-pancreatic anlages that recapitulate early morphogenetic events.
- Hiroyuki Koike
- , Kentaro Iwasawa
- & Takanori Takebe
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Letter |
A non-canonical Notch complex regulates adherens junctions and vascular barrier function
The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.
- William J. Polacheck
- , Matthew L. Kutys
- & Christopher S. Chen
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Letter |
Multilineage communication regulates human liver bud development from pluripotency
Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.
- J. Gray Camp
- , Keisuke Sekine
- & Barbara Treutlein
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Letter |
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
A new approach has been developed in order to achieve the stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells in a three-dimensional culture: this process, which mimics normal development and produces cells that have functional characteristics of mechanosensitive hair cells, is hoped to provide further insights into inner ear development and disorder.
- Karl R. Koehler
- , Andrew M. Mikosz
- & Eri Hashino
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Outlook |
Devices: Artificial inspiration
The donor lungs of the future — built from collagen or silicone rubber or engineered from donor organs stripped of their original cells — might give a new lease of life to COPD patients.
- Elie Dolgin
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News & Views |
Blood vessels on a chip
To understand how blood vessels form and function, scientists require reproducible systems that mimic living tissues. An innovative approach based on microfabricated vessels provides a key step towards this goal.
- Claudio Franco
- & Holger Gerhardt
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News Feature |
Tissue engineering: The brainmaker
With his knack for knowing what stem cells want, Yoshiki Sasai has grown an eye and parts of a brain in a dish.
- David Cyranoski
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Research Highlights |
Patching up the heart
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News |
Stem cells make 'retina in a dish'
Mouse cells have been coaxed into forming a retina, the most complex tissue yet engineered.
- Ewen Callaway
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Technology Feature |
A living system on a chip
For years, scientists have struggled to reconstruct tissues and organs by combining cells and nanotechnology. These devices are now edging from cool concept to practical application.
- Monya Baker
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Research Highlights |
Blood vessels on demand
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News |
Options for off-the-shelf blood vessels expand
Preliminary research could open the door to ready-to-use bioengineered veins.
- Tiffany O’Callaghan
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News Feature |
Food: A taste of things to come?
Researchers are sure that they can put lab-grown meat on the menu — if they can just get cultured muscle cells to bulk up.
- Nicola Jones
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Research Highlights |
Tissue engineering: Vision restored
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News |
Making lungs in the lab
Implanted tissue and microchip mimic both perform functions of lung.
- Alla Katsnelson