Featured
-
-
Article
| Open AccessIdentification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists
- Teresa Kaserer
- , Theresa Steinacher
- & Mariana Spetea
-
Article
| Open AccessRadiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages
- Olli Moisio
- , Senthil Palani
- & Anne Roivainen
-
Article
| Open AccessEpigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome
- David Reiner
- , Ludwig Seifert
- & Holger Stark
-
Article
| Open AccessTales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines
- Michael J. Cox
- , Steffen Jaensch
- & Hinrich W. H. Göhlmann
-
Article
| Open AccessThe diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission
- Leonid L. Moroz
- , Daria Y. Romanova
- & Dirk Fasshauer
-
Article
| Open AccessA small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition
- Irem Durmaz Sahin
- , Michael S. Christodoulou
- & Rengul Cetin-Atalay
-
Article
| Open AccessA novel silkworm infection model with fluorescence imaging using transgenic Trichosporon asahii expressing eGFP
- Yasuhiko Matsumoto
- , Hideki Yamazaki
- & Takashi Sugita
-
Article
| Open AccessMesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation
- Michael E. Stokes
- , Jonnell Candice Small
- & Brent R. Stockwell
-
Article
| Open AccessA site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors
- Kai-Cheng Hsu
- , Wei-Chun HuangFu
- & Jinn-Moon Yang
-
Article
| Open AccessHydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines
- Yudibeth Sixto-López
- , José Antonio Gómez-Vidal
- & José Correa-Basurto
-
Article
| Open Accessβ-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593
- Suresh Panthee
- , Naoko Kito
- & Shunji Takahashi
-
Article
| Open AccessGene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes
- Steffen Renner
- , Christian Bergsdorf
- & Pierre Farmer
-
Article
| Open AccessAllosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer
- Anton Cheltsov
- , Natsuko Nomura
- & Elmar Nurmemmedov
-
Article
| Open AccessDevelopment of Small Molecule MEIS Inhibitors that modulate HSC activity
- Raife Dilek Turan
- , Esra Albayrak
- & Fatih Kocabas
-
Article
| Open AccessInhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression
- Li-Wen Shen
- , Man-Qing Qian
- & Wen Zhang
-
Article
| Open AccessNucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix
- Cristina Medina-Trillo
- , Daniel M. Sedgwick
- & José Gallego
-
Article
| Open AccessExploring yeast interactions through metabolic profiling
- C. Roullier-Gall
- , V. David
- & H. Alexandre
-
Article
| Open AccessPyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1
- Michala G. Rolver
- , Line O. Elingaard-Larsen
- & Stine F. Pedersen
-
Article
| Open AccessSelective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
- Nathan J. Schauer
- , Xiaoxi Liu
- & Sara J. Buhrlage
-
Article
| Open AccessCellular metabolic activity marker via selective turn-ON detection of transporter protein using nitrobenzoxadiazole-based fluorescent reporter
- Tanoy Dutta
- , Kaushik Pal
- & Apurba L. Koner
-
Article
| Open AccessStructure-antioxidant activity relationship of methoxy, phenolic hydroxyl, and carboxylic acid groups of phenolic acids
- Jinxiang Chen
- , Jing Yang
- & Chan Kyung Kim
-
Article
| Open AccessAn efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity
- Fariba Peytam
- , Mehdi Adib
- & Alireza Foroumadi
-
Article
| Open AccessSynthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues
- Artem V. Artiukhov
- , Aneta Grabarska
- & Victoria I. Bunik
-
Article
| Open AccessPifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
- Jiawei Zhu
- , Madhurendra Singh
- & Sylvain Peuget
-
Article
| Open AccessDescribing the fecal metabolome in cryogenically collected samples from healthy participants
- Kajetan Trošt
- , Linda Ahonen
- & Cristina Legido-Quigley
-
Article
| Open AccessPhenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design
- Yaghoub Pourshojaei
- , Ardavan Abiri
- & Ali Asadipour
-
Article
| Open AccessSmall molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly
- Catherine D. Kim
- , Elizabeth D. Kim
- & Edward J. Wojcik
-
Article
| Open AccessAssessment of the potential of a reduced dose of dimethyl disulfide plus metham sodium on soilborne pests and cucumber growth
- Liangang Mao
- , Hongyun Jiang
- & Aocheng Cao
-
Article
| Open AccessStructural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
- Weijie You
- , Wei Zheng
- & Clemens Steegborn
-
Article
| Open AccessSeven-day Green Tea Supplementation Revamps Gut Microbiome and Caecum/Skin Metabolome in Mice from Stress
- Eun Sung Jung
- , Jong il Park
- & Choong Hwan Lee
-
Article
| Open AccessIdentification of potential chemosignals in the European water vole Arvicola terrestris
- Patricia Nagnan-Le Meillour
- , Amandine Descamps
- & Matthieu Keller
-
Article
| Open AccessA suicide inhibitor of nematode trehalose-6-phosphate phosphatases
- Megan Cross
- , Mark York
- & Andreas Hofmann
-
Article
| Open AccessA cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
- Pooja Sharma
- , Robert Mahen
- & Ashok R. Venkitaraman
-
Article
| Open AccessAmphiphilic Triazine Polymer Derivatives as Antibacterial And Anti-atopic Agents in Mice Model
- Pethaiah Gunasekaran
- , meiqi Fan
- & Jeong Kyu Bang
-
Article
| Open AccessNon-cytotoxic hydroxyl-functionalized exfoliated boron nitride nanoflakes impair the immunological function of insect haemocytes in vivo
- Elżbieta Czarniewska
- , Lucyna Mrówczyńska
- & Ewa Mijowska
-
Article
| Open AccessChemical Profiling of Volatile Organic Compounds in the Headspace of Algal Cultures as Early Biomarkers of Algal Pond Crashes
- Kristen L. Reese
- , Carolyn L. Fisher
- & Todd W. Lane
-
Article
| Open AccessPotent Phytotoxic Harziane Diterpenes from a Soft Coral-Derived Strain of the Fungus Trichoderma harzianum XS-20090075
- Dong-Lin Zhao
- , Lu-Jia Yang
- & Chang-Yun Wang
-
Article
| Open AccessVisualizing Alzheimer’s Disease Mouse Brain with Multispectral Optoacoustic Tomography using a Fluorescent probe, CDnir7
- Sung-Jin Park
- , Chris Jun Hui Ho
- & Young-Tae Chang
-
Article
| Open AccessRapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products
- Sayaka Masada
- , Genichiro Tsuji
- & Haruhiro Okuda
-
Article
| Open AccessSMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines
- Katharina Ehrenhöfer-Wölfer
- , Teresa Puchner
- & Simon Wöhrle
-
Article
| Open AccessDual-active antifungal agents containing strobilurin and SDHI-based pharmacophores
- Marco Zuccolo
- , Andrea Kunova
- & Sabrina Dallavalle
-
Article
| Open AccessGram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
- Cunyu Zhang
- , Katrina L. Creech
- & Timothy M. Willson
-
Article
| Open AccessGC-Recomposition-Olfactometry (GC-R) and multivariate study of three terpenoid compounds in the aroma profile of Angostura bitters
- Arielle J. Johnson
- , Anna K. Hjelmeland
- & Susan E. Ebeler
-
Article
| Open AccessSemisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish
- Yanqi Xie
- , Liliia M. Kril
- & Chunming Liu
-
Article
| Open AccessA Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death
- Eun-Yeong Kim
- , Tae-Wook Chung
- & Ki-Tae Ha
-
Article
| Open AccessExploration of the Structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its Transcriptional Regulation
- Xiaojie Cui
- , Han Chen
- & Jiang Zhou
-
Article
| Open AccessSuppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9
- Dmitry Kostyushev
- , Anastasiya Kostyusheva
- & Vladimir Chulanov
-
Article
| Open AccessA Novel Ruthenium-based Molecular Sensor to Detect Endothelial Nitric Oxide
- Achini K. Vidanapathirana
- , Benjamin J. Pullen
- & Peter J. Psaltis
-
Article
| Open AccessAryl Azides as Phosphine-Activated Switches for Small Molecule Function
- Bradley Lukasak
- , Kunihiko Morihiro
- & Alexander Deiters