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Skin cancer can involve melanocytes, leading to melanoma, but there are other non-melanoma skin cancers. These include basal cell carcinoma, squamous cell carcinoma and, less commonly, Merkel cell carcinoma, Kaposis sarcoma and T-cell lymphoma of the skin.
Treatment failure following chimaeric antigen receptor (CAR) T cell therapy is common yet incompletely understood. In this study, the authors demonstrate that deletion of the mitochondrial negative regulator, MCJ, in CAR T cells promotes target cell killing ex vivo and augments their efficacy in an in vivo B cell leukaemia model.
Leveraging the expertise of physicians to identify medically meaningful features in ‘counterfactual’ images produced via generative machine learning facilitates the auditing of the inference process of medical-image classifiers, as shown for dermatology images.
In this study, Bansaccal et al. analyse why, at some skin locations, oncogene-expressing cells rarely progress to cancer and found that a dense dermal collagen network prevents skin cancer formation.