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| Open AccessLong-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
- Huimei Wei
- , Johnathan E. LeSaint
- & Fang Zheng
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| Open AccessDARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin
- Lukas Becker
- & Andreas Plückthun
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| Open AccessThe IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity
- Shrayasee Saha
- , Amanda Sparkes
- & Jean Gariépy
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| Open AccessOptimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations
- Katharina Köchl
- , Tobias Schopper
- & Christian C. Gruber
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| Open AccessLong-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
- Nikola Stokovic
- , Natalia Ivanjko
- & Slobodan Vukicevic
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| Open AccessRAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines
- Caleb K. Stubbs
- , Marco Biancucci
- & Karla J. F. Satchell
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| Open AccessFc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
- Ella Fung
- , Liya Kang
- & Lidia Mosyak
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| Open AccessSelf-buffering capacity of a human sulfatase for central nervous system delivery
- Yi Wen
- , Nazila Salamat-Miller
- & Katherine Taylor
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| Open AccessLocal injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion
- Kevin O. Rivera
- , Fabrizio Russo
- & Chelsea S. Bahney
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| Open AccessThe influence of proline isomerization on potency and stability of anti-HIV antibody 10E8
- Miklos Guttman
- , Neal N. Padte
- & Kelly K. Lee
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| Open AccessDer p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy
- Rodrigo Lázaro-Gorines
- , Juan Carlos López-Rodríguez
- & Mayte Villalba
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| Open AccessA universal reporter cell line for bioactivity evaluation of engineered cytokine products
- Jacqueline Mock
- , Christian Pellegrino
- & Dario Neri
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| Open AccessThe ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability
- Tao Xie
- , Hui Fang
- & David M. Frucht
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| Open AccessImmune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection
- Jordan R. Yaron
- , Sriram Ambadapadi
- & Alexandra R. Lucas
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| Open AccessExploring the therapeutic potential of modern and ancestral phenylalanine/tyrosine ammonia-lyases as supplementary treatment of hereditary tyrosinemia
- Natalie M. Hendrikse
- , Albin Holmberg Larsson
- & Per-Olof Syrén
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| Open AccessSingle-cell dispensing and ‘real-time’ cell classification using convolutional neural networks for higher efficiency in single-cell cloning
- Julian Riba
- , Jonas Schoendube
- & Roland Zengerle
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| Open AccessProduction of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells
- Ondřej Vaněk
- , Petra Celadova
- & James R. Carlyle
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| Open AccessKunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma
- Shiwanthi L. Ranasinghe
- , Vanessa Rivera
- & Donald P. McManus
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| Open AccessEffects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
- Aikaterini Alexaki
- , Gaya K. Hettiarachchi
- & Chava Kimchi-Sarfaty
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| Open AccessBroad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins
- Erna Denkovskienė
- , Šarūnas Paškevičius
- & Aušra Ražanskienė
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| Open AccessStudies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold
- Matja Zalar
- , Sowmya Indrakumar
- & Alexander P. Golovanov
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| Open AccessThe In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1
- Simone Schadt
- , Christophe Husser
- & Nicole A. Kratochwil
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| Open AccessResponsive Cells for rhEGF bioassay Obtained through Screening of a CRISPR/Cas9 Library
- Xi Qin
- , Wenrong Yao
- & Junzhi Wang
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| Open AccessEnhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties
- George Vaniotis
- , Serge Moffett
- & Pnina Brodt
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| Open AccessEngineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance
- Saori Suzuki
- , Hiroaki Annaka
- & Ryutaro Asano
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| Open AccessSelective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection
- Hao Chen
- , Sriram Ambadapadi
- & Alexandra Lucas
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| Open AccessLysozyme and DNase I loaded poly (D, L lactide-co-caprolactone) nanocapsules as an oral delivery system
- Omar S. Abu Abed
- , Cheng Chaw
- & Amal A. Elkordy
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| Open AccessLysosomal Targeting Enhancement by Conjugation of Glycopeptides Containing Mannose-6-phosphate Glycans Derived from Glyco-engineered Yeast
- Ji-Yeon Kang
- , Keun Koo Shin
- & Doo-Byoung Oh
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| Open AccessDiscovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy
- Qiyue Hu
- , Xin Ye
- & Weikang Tao
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| Open AccessTrivalent soluble TNF Receptor, a potent TNF-α antagonist for the treatment collagen-induced arthritis
- Xiaofang Cui
- , Linmo Chang
- & Peng Liang
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| Open AccessGenetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets
- Yara Alenazi
- , Kamayani Singh
- & Shoumo Bhattacharya
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| Open AccessAffinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method
- Hideaki Sanada
- , Kazuki Kobayashi
- & Izumi Kumagai
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| Open AccessComprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
- Soo Min Noh
- , Seunghyeon Shin
- & Gyun Min Lee
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| Open AccessIn vivo depletion of serum IgG by an affibody molecule binding the neonatal Fc receptor
- Johan Seijsing
- , Shengze Yu
- & Torbjörn Gräslund
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| Open AccessGlyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing
- Yan Weng
- , Tetsuya Ishino
- & Laura Lin
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| Open AccessCharacterisation of the antibacterial properties of the recombinant phage endolysins AP50-31 and LysB4 as potent bactericidal agents against Bacillus anthracis
- Sangjin Park
- , Soo Youn Jun
- & Sang Hyeon Kang
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| Open AccessDiscovery of human-like L-asparaginases with potential clinical use by directed evolution
- Coraline Rigouin
- , Hien Anh Nguyen
- & Arnon Lavie
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| Open AccessImprovement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo
- Haipeng Liu
- , Danmei Su
- & Peng Liang
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| Open AccessYeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities
- Kamayani Singh
- , Graham Davies
- & Shoumo Bhattacharya
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| Open AccessScale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats
- Mozhgan Raigani
- , Mohammad-Reza Rouini
- & Fereidoun Mahboudi
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| Open AccessProtective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro
- Jian Wen
- , Yongbin Wu
- & Wenqi Dong
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| Open AccessEngineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
- Claire L. Dobson
- , Paul W. A. Devine
- & David C. Lowe
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| Open AccessBeyond Antibodies: Development of a Novel Protein Scaffold Based on Human Chaperonin 10
- Abdulkarim M. Alsultan
- , David Y. Chin
- & Stephen M. Mahler
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| Open AccessRecombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity
- Iris Munhoz Costa
- , Leonardo Schultz
- & Gisele Monteiro
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| Open AccessA long-acting GH receptor antagonist through fusion to GH binding protein
- Ian R. Wilkinson
- , Sarbendra L. Pradhananga
- & Richard J. Ross
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| Open AccessBiosimilar structural comparability assessment by NMR: from small proteins to monoclonal antibodies
- Boštjan Japelj
- , Gregor Ilc
- & Janez Plavec
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| Open AccessPre-Clinical Study of a Novel Recombinant Botulinum Neurotoxin Derivative Engineered for Improved Safety
- Edwin Vazquez-Cintron
- , Luis Tenezaca
- & Philip Band
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| Open AccessRecombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris
- Alexander Rodríguez-López
- , Carlos J. Alméciga-Díaz
- & Luis A. Barrera
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| Open AccessStanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury
- Luping Huang
- , Lin Zhang
- & David Sheikh-Hamad