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| Open AccessDiscovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
- Jonas Persson
- , Emmi Puuvuori
- & John Löfblom
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| Open AccessRational design of heterodimeric receptors capable of activating target signaling molecules
- Tatphon Kongkrongtong
- , Ruolan Zhang
- & Masahiro Kawahara
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| Open AccessA KLK4 proteinase substrate capture approach to antagonize PAR1
- Eitan Rabinovitch
- , Koishiro Mihara
- & Niv Papo
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| Open AccessImprove thermostability of Bacillus sp. TS chitosanase through structure-based alignment
- Zhanping Zhou
- & Xiao Wang
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| Open AccessComputational design of SARS-CoV-2 peptide binders with better predicted binding affinities than human ACE2 receptor
- Thassanai Sitthiyotha
- & Surasak Chunsrivirot
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| Open AccessEngineering of the genome editing protein Cas9 to slide along DNA
- Trishit Banerjee
- , Hiroto Takahashi
- & Kiyoto Kamagata
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| Open AccessA scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells
- Nadine Aschmoneit
- , Sophia Steinlein
- & Roland E. Kontermann
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| Open AccessDevelopment of a yeast cell surface display method using the SpyTag/SpyCatcher system
- Kaho Kajiwara
- , Wataru Aoki
- & Mitsuyoshi Ueda
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| Open AccessFunctional display of bioactive peptides on the vGFP scaffold
- Sharon Min Qi Chee
- , Jantana Wongsantichon
- & Farid J. Ghadessy
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| Open AccessA novel framework for engineering protein loops exploring length and compositional variation
- Pedro A. G. Tizei
- , Emma Harris
- & Vitor B. Pinheiro
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| Open AccessFc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
- Ella Fung
- , Liya Kang
- & Lidia Mosyak
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| Open AccessDirected evolution for high functional production and stability of a challenging G protein-coupled receptor
- Yann Waltenspühl
- , Jeliazko R. Jeliazkov
- & Andreas Plückthun
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| Open AccessSite-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response
- Adam M. Weiss
- , Jainu Ajit
- & Aaron P. Esser-Kahn
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| Open AccessNext generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo
- Maohua Li
- , Rongqing Zhao
- & Le Sun
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| Open AccessStructure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins
- Alessandro T. Caputo
- , Oliver M. Eder
- & Timothy E. Adams
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| Open AccessExploring targeting peptide-shell interactions in encapsulin nanocompartments
- Wiggert J. Altenburg
- , Nathan Rollins
- & Tobias W. Giessen
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| Open AccessStructural design principles for specific ultra-high affinity interactions between colicins/pyocins and immunity proteins
- Avital Shushan
- & Mickey Kosloff
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| Open AccessAn in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study
- Zikun Yang
- , Paul Bogdan
- & Shahin Nazarian
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| Open AccessA novel hyperthermophilic methylglyoxal synthase: molecular dynamic analysis on the regional fluctuations
- Gyo-Yeon Seo
- , Hoe-Suk Lee
- & Jinwon Lee
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| Open AccessNovel myostatin-specific antibody enhances muscle strength in muscle disease models
- Hiroyasu Muramatsu
- , Taichi Kuramochi
- & Junichi Nezu
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| Open AccessIn silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology
- Shaheen Bibi
- , Inayat Ullah
- & Shiquan Niu
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| Open AccessCharacterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering
- Aurélie Loussouarn
- , Ghislaine Béhar
- & Axelle Renodon-Cornière
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| Open AccessPredicting antibody affinity changes upon mutations by combining multiple predictors
- Yoichi Kurumida
- , Yutaka Saito
- & Tomoshi Kameda
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| Open AccessStructure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis
- Shuntaro Chiba
- , Aki Tanabe
- & Masateru Ohta
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| Open AccessMachine learning-guided discovery and design of non-hemolytic peptides
- Fabien Plisson
- , Obed Ramírez-Sánchez
- & Cristina Martínez-Hernández
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| Open AccessDesigning a multi-epitope peptide based vaccine against SARS-CoV-2
- Abhishek Singh
- , Mukesh Thakur
- & Kailash Chandra
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| Open AccessAncestral sequence reconstruction produces thermally stable enzymes with mesophilic enzyme-like catalytic properties
- Ryutaro Furukawa
- , Wakako Toma
- & Satoshi Akanuma
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| Open AccessIMPROvER: the Integral Membrane Protein Stability Selector
- Steven P. D. Harborne
- , Jannik Strauss
- & Adrian Goldman
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| Open AccessEngineered viral DNA polymerase with enhanced DNA amplification capacity: a proof-of-concept of isothermal amplification of damaged DNA
- Carlos D. Ordóñez
- , Ana Lechuga
- & Modesto Redrejo-Rodríguez
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| Open AccessNearest-neighbor amino acids of specificity-determining residues influence the activity of engineered Cre-type recombinases
- Anjali Soni
- , Martina Augsburg
- & M. Teresa Pisabarro
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| Open AccessEngineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity
- Jesse M. Marangoni
- , Sau-Ching Wu
- & Kenneth K. S. Ng
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| Open AccessDiB-splits: nature-guided design of a novel fluorescent labeling split system
- Nina G. Bozhanova
- , Alexey S. Gavrikov
- & Jens Meiler
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| Open AccessBuild-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats
- Ryutaro Asano
- , Katsuhiro Hosokawa
- & Izumi Kumagai
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| Open AccessModification of an Anopheles gambiae odorant binding protein to create an array of chemical sensors for detection of drugs
- Khasim Cali
- & Krishna C. Persaud
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| Open AccessComplex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide
- Denis S. Kudryavtsev
- , Valentin М. Tabakmakher
- & Victor I. Tsetlin
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Article
| Open AccessEvolved Fusarium oxysporum laccase expressed in Saccharomyces cerevisiae
- Natalia Kwiatos
- , Marzena Jędrzejczak-Krzepkowska
- & Stanisław Bielecki
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| Open AccessReplacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions
- Douglas J. Swartz
- , Anukriti Singh
- & Ina L. Urbatsch
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| Open AccessDesign Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use
- Tetsuya Kadonosono
- , Wanaporn Yimchuen
- & Shinae Kizaka-Kondoh
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| Open AccessDevelopment of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering
- Jaana Haka
- , Merja H. Niemi
- & Juha Rouvinen
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| Open AccessThe CC′ loop of IgV domains of the immune checkpoint receptors, plays a key role in receptor:ligand affinity modulation
- Shankar V. Kundapura
- & Udupi A. Ramagopal
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| Open AccessComputational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β2-adrenergic receptor (β2-AR)
- Milan Sencanski
- , Sanja Glisic
- & Milka Vrecl
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| Open AccessRigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts
- Patrick Ernst
- , Annemarie Honegger
- & Andreas Plückthun
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| Open AccessmRhubarb: Engineering of monomeric, red-shifted, and brighter variants of iRFP using structure-guided multi-site mutagenesis
- Oliver C. Rogers
- , Dorothy M. Johnson
- & Elad Firnberg
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| Open AccessA 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3
- Anna Gärtner
- , Anna Joëlle Ruff
- & Ulrich Schwaneberg
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| Open AccessStructural analysis of biological targets by host:guest crystal lattice engineering
- Patrick Ernst
- , Andreas Plückthun
- & Peer R. E. Mittl
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| Open AccessFusion proteins with chromogenic and keratin binding modules
- Ana Tinoco
- , Egipto Antunes
- & Artur Ribeiro
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| Open AccessPrediction of MAYV peptide antigens for immunodiagnostic tests by immunoinformatics and molecular dynamics simulations
- Roger Luiz Rodrigues
- , Gabriela De Lima Menezes
- & Roosevelt Alves Da Silva
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| Open AccessA comprehensive computational study of amino acid interactions in membrane proteins
- Mame Ndew Mbaye
- , Qingzhen Hou
- & Marianne Rooman
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| Open AccessEngineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen
- Adrian Hohl
- , Ram Karan
- & Jörg Eppinger