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The mechanisms underlying adaptive response to the stress elicited by radiotherapy in glioma cells remains unclear. Here, the authors show that therapeutic ionizing radiation induces rapid genome-wide chromatin reorganization to facilitate P-TEFb-mediated nascent transcriptional induction, which could be targeted to sensitize radiotherapy response in glioma.
Treatment failure following chimaeric antigen receptor (CAR) T cell therapy is common yet incompletely understood. In this study, the authors demonstrate that deletion of the mitochondrial negative regulator, MCJ, in CAR T cells promotes target cell killing ex vivo and augments their efficacy in an in vivo B cell leukaemia model.
Tam et al. compare molecular features between adolescents and young adult (AYA) and older adult (OA) patients with soft tissue tumours and identify that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients.
Although childhood cancer survival rates have increased globally, there is a markedly inequitable distribution of these advances. Here, Monica Gramatges summarizes these challenges and provides the reader with strategies and solutions that begin to address factors that contribute to these inequities.