Mitochondria articles within Scientific Reports

Featured

• Editorial
  30 April 2024 | Open Access

  Mitochondrial dynamics: updates and perspectives

  Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.

  • Kezhong Zhang
  •  & Ježek Petr

• Article
  30 April 2024 | Open Access

  Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions

  • Nina Kunová
  • , Gabriela Ondrovičová
  •  & Vladimír Pevala

• Article
  11 April 2024 | Open Access

  Mitochondrial Ca²⁺ signaling is a hallmark of specific adipose tissue-cancer crosstalk

  • Agnese De Mario
  • , Elisabetta Trevellin
  •  & Cristina Mammucari

• Article
  09 April 2024 | Open Access

  Balbiani body of basal insects is potentially involved in multiplication and selective elimination of mitochondria

  • Malgorzata Sekula
  • , Waclaw Tworzydlo
  •  & Szczepan M. Bilinski

• Article
  28 March 2024 | Open Access

  Bioenergetic impairment in Gulf War illness assessed via ³¹P-MRS

  • Beatrice Alexandra Golomb
  • , Jun Hee Han
  •  & Gavin Hamilton

• Article
  26 March 2024 | Open Access

  Microcirculation-driven mitochondrion dysfunction during the progression of experimental sepsis

  • Roland Fejes
  • , Attila Rutai
  •  & Szabolcs Péter Tallósy

• Article
  19 March 2024 | Open Access

  MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4

  • Jianbing Zhu
  • , Qian Wang
  •  & Junbo Ge

• Article
  06 February 2024 | Open Access

  Vitamin K2 protects mice against non-alcoholic fatty liver disease induced by high-fat diet

  • Peizuo Zhao
  • , Weidong Yang
  •  & Shuzhuang Li

• Article
  09 January 2024 | Open Access

  Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

  • Doménica Tarallo
  • , Jennyfer Martínez
  •  & Celia Quijano

• Article
  04 January 2024 | Open Access

  The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast

  • Yuan Tian
  •  & Koji Okamoto

• Article
  08 December 2023 | Open Access

  Arresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage

  • Pangda Sopha Sushadi
  • , Maiko Kuwabara
  •  & Atsushi Asano

• Article
  07 December 2023 | Open Access

  Characteristics and time points to inhibit ferroptosis in human osteoarthritis

  • Yangyang Xu
  • , Zhenyu Yang
  •  & Qingqi Meng

• Article
  01 November 2023 | Open Access

  A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise

  • Kirsten T. Nijholt
  • , Pablo I. Sánchez-Aguilera
  •  & B. Daan Westenbrink

• Article
  05 October 2023 | Open Access

  Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

  • Ilya N. Boykov
  • , McLane M. Montgomery
  •  & Kelsey H. Fisher-Wellman

• Article
  27 September 2023 | Open Access

  MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response

  • Danhong Lin
  • , Jingwen Yu
  •  & Huibiao Quan

• Article
  21 September 2023 | Open Access

  Characterization of signal and transit peptides based on motif composition and taxon-specific patterns

  • Katarzyna Sidorczuk
  • , Paweł Mackiewicz
  •  & Przemysław Gagat

• Article
  15 September 2023 | Open Access

  Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation

  • Nicole DeFoor
  • , Swagatika Paul
  •  & Alicia M. Pickrell

• Article
  02 September 2023 | Open Access

  Enhanced presynaptic mitochondrial energy production is required for memory formation

  • Erica L. Underwood
  • , John B. Redell
  •  & Pramod K. Dash

• Article
  29 August 2023 | Open Access

  Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6

  • James M. Gruschus
  • , Daniel L. Morris
  •  & Nico Tjandra

• Article
  25 July 2023 | Open Access

  Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy

  • Hiroko Ueda
  • , Quynh Thuy Huong Tran
  •  & Hiroyasu Tsukaguchi

• Article
  14 July 2023 | Open Access

  Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency

  • K. L. Stauch
  • , S. Totusek
  •  & H. S. Fox

• Article
  06 June 2023 | Open Access

  Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin

  • David M. Ross
  • , Hai Po Helena Liang
  •  & Vivien M. Chen

• Article
  24 May 2023 | Open Access

  Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

  • Kim Reid
  • , Eileen G. Daniels
  •  & Keir J. Menzies

• Article
  23 May 2023 | Open Access

  PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

  • Vera H. W. de Wit-Verheggen
  • , Vera B. Schrauwen-Hinderling
  •  & Tineke van de Weijer

• Article
  10 May 2023 | Open Access

  Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

  • R. Undamatla
  • , O. G. Fagunloye
  •  & M. J. Jurczak

• Article
  06 May 2023 | Open Access

  Mitochondrial citrate metabolism and efflux regulate BeWo differentiation

  • Renee M. Mahr
  • , Snehalata Jena
  •  & Sarah A. Wernimont

• Article
  08 April 2023 | Open Access

  Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells

  • Vojtěch Pavluch
  • , Tomáš Špaček
  •  & Petr Ježek

• Article
  28 February 2023 | Open Access

  Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization

  • Sébastien Méthot
  • , Stéphanie Proulx
  •  & Patrick J. Rochette

• Article
  10 February 2023 | Open Access

  The injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse

  • Yovita Permata Budi
  • , Meng-Chieh Hsu
  •  & Yi-Fan Jiang

• Article
  02 January 2023 | Open Access

  Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy

  • Kibrom M. Alula
  • , Yaritza Delgado-Deida
  •  & Arianne L. Theiss

• Article
  21 December 2022 | Open Access

  Sex and menopause impact ³¹P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with ¹¹C-PiB PET amyloid-beta load

  • Steven Jett
  • , Jonathan P. Dyke
  •  & Lisa Mosconi

• Article
  14 December 2022 | Open Access

  An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

  • Agalya Periasamy
  • , Naomi Mitchell
  •  & Jacqueline M. Gulbis

• Article
  07 December 2022 | Open Access

  Superior cardiometabolic and cellular adaptive responses to multiple versus single daily sessions of high-intensity interval training in Wistar rats

  • Bruno Ferreira Mendes
  • , Liliane Vanessa Costa-Pereira
  •  & Marco Fabrício Dias-Peixoto

• Article
  07 December 2022 | Open Access

  The mitochondrial Ca²⁺ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca²⁺ oscillations

  • Akshar Patel
  • , Matthew Simkulet
  •  & B. Rita Alevriadou

• Article
  23 November 2022 | Open Access

  Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice

  • Baiyang You
  • , Jing Cheng
  •  & Suixin Liu

• Article
  18 November 2022 | Open Access

  Delivery of the reduced form of vitamin K₂₍₂₀₎ to NIH/3T3 cells partially protects against rotenone induced cell death

  • Erina Toki
  • , Shotaro Goto
  •  & Jiro Takata

• Article
  19 October 2022 | Open Access

  Mesenchymal stem cell bioenergetics and apoptosis are associated with risk for bronchopulmonary dysplasia in extremely low birth weight infants

  • Snehashis Hazra
  • , Rui Li
  •  & Jegen Kandasamy

• Article
  12 October 2022 | Open Access

  Universal dynamics of mitochondrial networks: a finite-size scaling analysis

  • Nahuel Zamponi
  • , Emiliano Zamponi
  •  & Dante R. Chialvo

• Article
  29 September 2022 | Open Access

  Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization

  • Natalia Andelova
  • , Iveta Waczulikova
  •  & Miroslav Ferko

• Article
  27 September 2022 | Open Access

  Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos

  • Marta Czernik
  • , Dawid Winiarczyk
  •  & Pasqualino Loi

• Article
  27 September 2022 | Open Access

  The relationships between growth rate and mitochondrial metabolism varies over time

  • Jean-Baptiste Quéméneur
  • , Morgane Danion
  •  & Karine Salin

• Article
  02 August 2022 | Open Access

  Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines

  • Maria Carmo Greier
  • , Annette Runge
  •  & Herbert Riechelmann

• Article
  01 July 2022 | Open Access

  In-resin CLEM of Epon-embedded cells using proximity labeling

  • Takahito Sanada
  • , Junji Yamaguchi
  •  & Yasuo Uchiyama

• Article
  27 June 2022 | Open Access

  Evidence for mitochondrial Lonp1 expression in the nucleus

  • Lara Gibellini
  • , Rebecca Borella
  •  & Marcello Pinti

• Article
  31 May 2022 | Open Access

  Reconstruction of functional human epidermis equivalent containing 5%IPS-derived keratinocytes treated with mitochondrial stimulating plant extracts

  • Marielle Moreau
  • , Christophe Capallere
  •  & Anne-Laure Bulteau

• Article
  06 May 2022 | Open Access

  Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells

  • Luke Goudie
  • , Nicole L. Mancini
  •  & Jane Shearer

• Article
  07 April 2022 | Open Access

  The SNPs of mitochondrial DNA displacement loop region and mitochondrial DNA copy number associated with risk of polymyositis and dermatomyositis

  • Yufei Zhao
  • , Chenxing Peng
  •  & Zhanjun Guo

• Article
  22 March 2022 | Open Access

  Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect

  • Daisuke Sasaki
  • , Jiro Abe
  •  & Yuma Yamada

• Article
  10 February 2022 | Open Access

  Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

  • V. F. E. D. Smolders
  • , C. Rodríguez
  •  & O. Tura-Ceide

• Article
  19 January 2022 | Open Access

  Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

  • Matthew C. Frise
  • , David A. Holdsworth
  •  & Peter A. Robbins