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| Open AccessChronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities
- Gerd Schreurs
- , Stuart Maudsley
- & Benjamin A. Vervaet
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| Open AccessDisease pathology signatures in a mouse model of Mucopolysaccharidosis type IIIB
- Ralitsa Petrova
- , Abhijeet R. Patil
- & Jennifer R. Stratton
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| Open AccessInhibition of CysLTR1 reduces the levels of aggregated proteins in retinal pigment epithelial cells
- Andreas Koller
- , Susanne Maria Brunner
- & Andrea Trost
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| Open AccessSortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells
- Andrea Carolina Aguilera
- , Natalia Leiva
- & Lorena Carvelli
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| Open AccessCorrection of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy
- Hiroyuki Nakamura
- , Tsutomu Tanaka
- & John A. Chiorini
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| Open AccessQuantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells
- Alice Dupont Juhl
- , Christian W. Heegaard
- & Daniel Wüstner
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Article
| Open AccessIdentification of critical amino acid residues in the regulatory N-terminal domain of PMEL
- Susan M. Mitchell
- , Morven Graham
- & Ralf M. Leonhardt
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| Open AccessCalciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells
- Rina Kunishige
- , Mai Mizoguchi
- & Masayuki Murata
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| Open AccessFormaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
- Thomas J. M. Michiels
- , Hugo D. Meiring
- & Bernard Metz
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| Open AccessGlobal analysis of protein degradation in prion infected cells
- Charles R. Hutti
- , Kevin A. Welle
- & Sina Ghaemmaghami
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| Open AccessCathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes
- Yuhei Mizunoe
- , Masaki Kobayashi
- & Yoshikazu Higami
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| Open AccessTargeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation
- Sylwia Jones
- , Peter J. King
- & Daniel Hochhauser
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| Open AccessSelective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
- Marina García-Macia
- , Adrián Santos-Ledo
- & Ana Coto-Montes
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| Open AccessRole of Atg8 in the regulation of vacuolar membrane invagination
- Ayane Ishii
- , Kazuo Kurokawa
- & Yoko Kimura
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Article
| Open AccessMacrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking
- Spencer Goodman
- , Swati Naphade
- & Stephanie Cherqui
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Article
| Open AccessBK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation
- Nabab Khan
- , Koffi L. Lakpa
- & Xuesong Chen
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| Open AccessIdentification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe
- Shunsuke Ishii
- , Akira Matsuura
- & Eisuke Itakura
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Article
| Open AccessExtracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
- Anna-Carin Hoffmann
- , Georgia Minakaki
- & Wei Xiang
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| Open AccessAutophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease
- Jessie Adams
- , Melissa Feuerborn
- & Stella Y. Lee
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| Open AccessDual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
- Johannes Ridinger
- , Emily Koeneke
- & Ina Oehme
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| Open AccessEssential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment
- Naomi Matsumoto
- , Mizuki Sekiya
- & Mayumi Nakanishi-Matsui
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| Open AccessPhotoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)
- Camille Dejos
- , Sharee Kuny
- & Yves Sauvé
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| Open AccessStimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels
- Jonathan M. Beckel
- , Néstor Más Gómez
- & Claire H. Mitchell
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| Open AccessTransit and integration of extracellular mitochondria in human heart cells
- Douglas B. Cowan
- , Rouan Yao
- & James D. McCully
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Article
| Open AccessThe Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor
- Benoît T. Roux
- , Claudia C. Bauer
- & Graeme S. Cottrell
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| Open AccessEndocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons
- Zsombor Koszegi
- , Maria Fiuza
- & Jonathan G. Hanley
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| Open AccessFMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
- Frieda Kage
- , Anika Steffen
- & Klemens Rottner
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| Open AccessHIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
- Alessandro Cinti
- , Valerie Le Sage
- & Andrew J. Mouland
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| Open Access2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway
- Jason Gaspar
- , Jacques Mathieu
- & Pedro Alvarez
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| Open AccessRecombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels
- Nicole Bobak
- , Sylvain Feliciangeli
- & Florian Lesage
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Article
| Open AccessAcute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis
- Lorena Fernández-Mosquera
- , Cátia V. Diogo
- & Nuno Raimundo
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| Open AccessApigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- Chung-Ming Lin
- , Hsin-Han Chen
- & Hui-Jye Chen
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Article
| Open AccessActin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K
- Saori Ohmae
- , Naruto Noma
- & Masataka Asagiri
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Article
| Open AccessThe human two-pore channel 1 is modulated by cytosolic and luminal calcium
- Laura Lagostena
- , Margherita Festa
- & Armando Carpaneto
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Article
| Open AccessUbiquitination and dynactin regulate TMEPAI lysosomal trafficking
- Shenheng Luo
- , Lei Jing
- & Aipo Diao
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| Open AccessTFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry
- Luigi Sbano
- , Massimo Bonora
- & Paolo Pinton
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| Open AccessNanoimaging granule dynamics and subcellular structures in activated mast cells using soft X-ray tomography
- Huan-Yuan Chen
- , Dapi Meng-Lin Chiang
- & Fu-Tong Liu
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| Open AccessBK channel agonist represents a potential therapeutic approach for lysosomal storage diseases
- Xi Zoë Zhong
- , Xue Sun
- & Xian-Ping Dong
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| Open AccessTranslocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
- Kosuke Kawaguchi
- , Takumi Okamoto
- & Tsuneo Imanaka
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| Open AccessLRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
- Tomoki Kuwahara
- , Keiichi Inoue
- & Asa Abeliovich
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| Open AccessExtracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation
- Petra Wäster
- , Ida Eriksson
- & Karin Öllinger
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| Open AccessA C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum
- Lichang Wu
- , Yu Sun
- & Yinchuan Li
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| Open AccessA melanosomal two-pore sodium channel regulates pigmentation
- Nicholas W. Bellono
- , Iliana E. Escobar
- & Elena Oancea
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| Open AccessATP-containing vesicles in stria vascular marginal cell cytoplasms in neonatal rat cochlea are lysosomes
- Jun Liu
- , Wenjing Liu
- & Jun Yang
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| Open AccessThe AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane
- Elisa Llinares
- , Abdoulaye Oury Barry
- & Bruno André
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| Open AccessMapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation
- Maria Merkulova
- , Teodor G. Păunescu
- & Dennis Brown
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Article
| Open AccessComprehensive Proteomics Analysis of Laticifer Latex Reveals New Insights into Ethylene Stimulation of Natural Rubber Production
- Xuchu Wang
- , Dan Wang
- & Zheng Tong
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| Open AccessProtease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity
- Regina Freier
- , Elfriede Dall
- & Hans Brandstetter
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| Open AccessBBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors
- Qingwen Xu
- , Yuxia Zhang
- & Jinghua Hu