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| Open AccessDown-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts
- Xiaohui Liu
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| Open AccessKinetics and thermodynamics of the protein-ligand interactions in the riboflavin kinase activity of the FAD synthetase from Corynebacterium ammoniagenes
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| Open AccessDYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain
- Samira Abu Jhaisha
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| Open AccessA functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity
- R. Sumanth Iyer
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| Open AccessFusaric Acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cells
- Shanel Dhani
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- & Anil A. Chuturgoon
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| Open AccessDevelopment of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy
- Yukiya Sako
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| Open AccessPhosphoproteome Analysis Reveals Phosphorylation Underpinnings in the Brains of Nurse and Forager Honeybees (Apis mellifera)
- Gebreamlak Bezabih
- , Han Cheng
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| Open AccessCombined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro
- Maruša Bizjak
- , Petra Malavašič
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| Open AccessRole of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase
- Rana J. T. Al-Baghdadi
- , Inna A. Nikonorova
- & Tracy G. Anthony
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| Open AccessDifferential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop
- Mathias Cobbaut
- , Rita Derua
- & Johan Van Lint
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| Open AccessRassf Proteins as Modulators of Mst1 Kinase Activity
- Aruna Bitra
- , Srinivas Sistla
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| Open AccessDifferential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas
- Isabel Weigand
- , Cristina L. Ronchi
- & Silviu Sbiera
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| Open AccessAuto-phosphorylation Represses Protein Kinase R Activity
- Die Wang
- , Nicole A. de Weerd
- & Anthony J. Sadler
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| Open AccessNovel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue
- Z. Orfi
- , F. Waczek
- & A. Ullrich
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| Open AccessALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation
- Reddy Ranjith K. Sama
- , Claudia Fallini
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| Open AccessD-Glutamate is metabolized in the heart mitochondria
- Makoto Ariyoshi
- , Masumi Katane
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| Open AccessNuclear relocation of Kss1 contributes to the specificity of the mating response
- Serge Pelet
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| Open AccessRegulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
- Maria Perander
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| Open AccessImpact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation
- Matthew T. O’Brien
- , Jonathan S. Oakhill
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| Open AccessInhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM
- Sarah Keenan
- , Sarah J. Wetherill
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| Open AccessMass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases
- Na Cai
- , Zhiyong Bai
- & Loren W. Runnels
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| Open AccessGeneration and quantitative proteomics analysis of CK2α/α’(−/−) cells
- Christian Borgo
- , Cinzia Franchin
- & Lorenzo A. Pinna
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| Open AccessSuppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1
- Ee Soo Lee
- , Llorenç Solé Boldo
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| Open AccessZinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways
- Hyun-A Seong
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| Open AccessPharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions
- Su Gao
- , Shannon Howard
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| Open AccessCyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation
- Chengcheng Liu
- , Xiaoyan Zhai
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| Open AccessMethionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions
- Francisco J. Veredas
- , Francisco R. Cantón
- & J. Carlos Aledo
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| Open AccessNiclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes
- Md. Kamrul Hasan Chowdhury
- , Nigel Turner
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| Open AccessConformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET
- Louis Perdios
- , Alan R. Lowe
- & Matilda Katan
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| Open AccessInteraction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway
- Tomoaki Ohtsuka
- , Masakiyo Sakaguchi
- & Shinichi Toyooka
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| Open Accessβ-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
- Nada Ali
- , Naomi Ling
- & Paul R. Gooley
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| Open AccessGSK-3β controls NF-kappaB activity via IKKγ/NEMO
- Senad Medunjanin
- , Lisa Schleithoff
- & Ruediger C. Braun-Dullaeus
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| Open AccessDeletion of Lkb1 in adult mice results in body weight reduction and lethality
- Tizhong Shan
- , Yan Xiong
- & Shihuan Kuang
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| Open AccessFunctional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain
- Jinwei Zhang
- , Geng Gao
- & Kristopher T. Kahle
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| Open AccessProtein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ
- Nisha Durand
- , Ligia I. Bastea
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| Open AccessMolecular characterization of host-parasite cell signalling in Schistosoma mansoni during early development
- Margarida Ressurreição
- , Firat Elbeyioglu
- & Anthony J. Walker
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| Open AccessAttenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment
- Wenchao Sun
- , Seongsoo Lee
- & Jayakumar Rajadas
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| Open AccessHierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites
- Boris Prinz
- , Katherine L. Harvey
- & Tim W. Gilberger
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| Open AccessPharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
- E. Lobbestael
- , L. Civiero
- & V. Baekelandt
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| Open AccessThe PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer
- Heike Döppler
- , Richard Panayiotou
- & Peter Storz
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| Open AccessThe analysis of heterotaxy patients reveals new loss-of-function variants of GRK5
- Davor Lessel
- , Tariq Muhammad
- & Melanie Philipp
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| Open AccessA novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells
- Abdulhameed Al-Ghabkari
- , Jing-Ti Deng
- & Justin A. MacDonald
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| Open AccessAMPK-independent inhibition of human macrophage ER stress response by AICAR
- Marcel Boß
- , Yvette Newbatt
- & Dmitry Namgaladze
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| Open AccessMolecular hydrogen suppresses activated Wnt/β-catenin signaling
- Yingni Lin
- , Bisei Ohkawara
- & Kinji Ohno
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| Open AccessImatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy
- Yuko Tsutsui
- , Daniel Deredge
- & Franklin A. Hays
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Article
| Open AccessDose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor
- Emily E. Way
- , Giraldina Trevejo-Nunez
- & Kong Chen
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| Open AccessComparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ
- Yasumitsu Kondoh
- , Kaori Honda
- & Hiroyuki Osada
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Article
| Open AccessOver-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation
- Bing Zheng
- , Jia-Hui Mao
- & Xiao-dong Pan
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Article
| Open AccessA metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant
- Anice Sabag-Daigle
- , Henry M. Blunk
- & Brian M. M. Ahmer