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| Open AccessIsland-specific evolution of a sex-primed autosome in a sexual planarian
Assembly and analysis of the Schmidtea mediterranea genome indicate that this planarian’s chromosome 1 may be evolving into a sex chromosome.
- Longhua Guo
- , Joshua S. Bloom
- & Leonid Kruglyak
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Article
| Open AccessMultiple wheat genomes reveal global variation in modern breeding
Comparison of multiple genome assemblies from wheat reveals extensive diversity that results from the complex breeding history of wheat and provides a basis for further potential improvements to this important food crop.
- Sean Walkowiak
- , Liangliang Gao
- & Curtis J. Pozniak
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Ancient West African foragers in the context of African population history
Genome-wide ancestry profiles of four individuals, dating to 8,000 and 3,000 years before present, from the archaeological site of Shum Laka (Cameroon) shed light on the deep population history of sub-Saharan Africa.
- Mark Lipson
- , Isabelle Ribot
- & David Reich
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Article
| Open AccessThe UK Biobank resource with deep phenotyping and genomic data
Deep phenotype and genome-wide genetic data from 500,000 individuals from the UK Biobank, describing population structure and relatedness in the cohort, and imputation to increase the number of testable variants to 96 million.
- Clare Bycroft
- , Colin Freeman
- & Jonathan Marchini
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Letter
| Open AccessDe novo assembly and phasing of a Korean human genome
De novo assembly and phasing of the genome of an individual from Korea using a combination of different sequencing approaches provides a useful population-specific reference genome and represents the most contiguous human genome assembly so far.
- Jeong-Sun Seo
- , Arang Rhie
- & Changhoon Kim
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Schizophrenia risk from complex variation of complement component 4
WebSchizophrenia is associated with genetic variation at the major histocompatibility complex locus; this study reveals that alleles at this locus associate with schizophrenia in proportion to their tendency to generate greater expression of complement component 4 (C4A) genes and that C4 promotes the elimination of synpases.
- Aswin Sekar
- , Allison R. Bialas
- & Steven A. McCarroll
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Letter |
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line
Haplotype-resolved whole-genome sequencing of the HeLa CCL-2 strain shows that HeLa is relatively stable in terms of point variation; integration of several data sets reveals strong, haplotype-specific activation of the proto-oncogene MYC by the human papilloma virus type 18 genome, and enables the relationship between gene dosage and expression to be examined.
- Andrew Adey
- , Joshua N. Burton
- & Jay Shendure
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Letter |
Serial translocation by means of circular intermediates underlies colour sidedness in cattle
Colour sidedness in cattle breeds is reported to be determined by two alleles, created as a result of a serial translocation involving circular intermediates.
- Keith Durkin
- , Wouter Coppieters
- & Carole Charlier
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Letter |
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, was conducted to shed light on the process of dog diversification. The results reveal that much of genome diversity came from Middle Eastern progenitors, combined with interbreeding with local wolf populations, and that recent evolution involved limited genetic variation to create the phenotypic diversity of modern dogs.
- Bridgett M. vonHoldt
- , John P. Pollinger
- & Robert K. Wayne