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| Open AccessIdentification of potential new COVID-19 treatments via RWD-driven drug repurposing
- Yun Liao
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| Open AccessTargeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer
- Hamid Jamialahmadi
- , Seyedeh Elnaz Nazari
- & Amir Avan
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| Open AccessGreen “turn-off” luminescent nanosensors for the sensitive determination of desperately fluorescent antibacterial antiviral agent and its metabolite in various matrices
- Hadil M. Elbardisy
- , Mai M. Elnaggar
- & Amira F. El-Yazbi
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| Open AccessExperimental solubility of aripiprazole in supercritical carbon dioxide and modeling
- Eslam Ansari
- , Bizhan Honarvar
- & Mehdi Azizi
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| Open AccessDeveloping a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy
- Noam Tzuri
- , Ksenia M. Yegodayev
- & Niv Papo
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| Open AccessNVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling
- Qing Tong
- , Dong Yan
- & Mingyu Yi
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| Open AccessPreclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment
- Derek Allen
- , Samerender Nagam Hanumantharao
- & Paul Blum
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| Open AccessIdentification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX
- M. Hetmann
- , C. Langner
- & C. C. Gruber
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| Open AccessDesign of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity
- Zahra Rashno
- , Elham Rismani
- & Majid Fasihi Harandi
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| Open AccessAmelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in Long Evans rats
- Fatima Tuj Johra
- , Sukria Hossain
- & Hasan Mahmud Reza
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| Open AccessUse of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma
- Minhua Hu
- , Hongsong Yan
- & Hang Dong
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| Open AccessOligonucleotide mapping via mass spectrometry to enable comprehensive primary structure characterization of an mRNA vaccine against SARS-CoV-2
- Brian C. Gau
- , Andrew W. Dawdy
- & Jason C. Rouse
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Article
| Open AccessCombination of triheptanoin with the ketogenic diet in Glucose transporter type 1 deficiency (G1D)
- Adrian Avila
- , Ignacio Málaga
- & Juan M. Pascual
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| Open AccessHeterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model
- Laurel Robbins
- , Ariane Balaram
- & William H. Conrad
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| Open AccessUnlocking multidimensional cancer therapeutics using geometric data science
- Deepak Parashar
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| Open AccessEffects of lidocaine incorporation (without epinephrine) on pain and 2-week complications of botulinum toxin: a double-blind randomized placebo-controlled clinical trial
- Farzin Sarkarat
- , Diba Bagheri
- & Vahid Rakhshan
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| Open AccessEvaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models
- Philip Schippers
- , Sari Rasheed
- & Markus R. Meyer
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| Open AccessEfficacy and safety profile of intravitreal dexamethasone implant versus antivascular endothelial growth factor treatment in diabetic macular edema: a systematic review and meta-analysis
- Sheng-Chu Chi
- , Yi-No Kang
- & Yi-Ming Huang
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| Open AccessStandardized Centella asiatica (ECa 233) extract decreased pain hypersensitivity development in a male mouse model of chronic inflammatory temporomandibular disorder
- Nattapon Rotpenpian
- , Aree Wanasuntronwong
- & Narawut Pakaprot
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| Open AccessBiosynthesis and characterization of zinc oxide nanoparticles using Nigella sativa against coccidiosis in commercial poultry
- Najam-ul Lail
- , Adeel Sattar
- & Mashal M. Almutairi
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| Open AccessBee venom as an alternative for antibiotics against Staphylococcus aureus infections
- Ahmed Sameh
- , Amr A. Gouda
- & Azza El Amir
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| Open AccessDevelopment of UPLC method for simultaneous assay of some COVID-19 drugs utilizing novel instrumental standard addition and factorial design
- Hanan I. El-Shorbagy
- , Mona A. Mohamed
- & Fathalla Belal
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| Open AccessTransport of Designed Ankyrin Repeat Proteins through reconstituted human bronchial epithelia and protection against SARS-CoV-2
- Lisa Künzi
- , Sarah Ryter
- & Marianne Geiser
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| Open AccessChannel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites
- Marina Sherif Fam
- , Christine Adel Sedky
- & Ulrike Breitinger
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| Open AccessResults of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder
- Lauren M. Schmitt
- , Elizabeth G. Smith
- & Craig A. Erickson
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| Open AccessA Phase 1 randomized study on the safety and pharmacokinetics of OCS-05, a neuroprotective disease modifying treatment for Acute Optic Neuritis and Multiple Sclerosis
- Pablo Villoslada
- , Mar Masso
- & Annelize Koch
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| Open AccessTRAF6 as a potential target in advanced breast cancer: a systematic review, meta-analysis, and bioinformatics validation
- Feier Zeng
- , Giovana Carrasco
- & Aymen I. Idris
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| Open AccessLoco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models
- Lisa Gherardini
- , Veronica Vetri Buratti
- & Mario Chiariello
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| Open AccessDeduction of the operable design space of RP-HPLC technique for the simultaneous estimation of metformin, pioglitazone, and glimepiride
- Aya A. Marie
- , Sherin F. Hammad
- & Amira H. Kamal
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Article
| Open AccessDefining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers
- Elena C. Gross
- , Niveditha Putananickal
- & Adrian Soto-Mota
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| Open AccessA multicenter phase II trial of anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative breast cancer
- Christoph Mamot
- , Andreas Wicki
- & Christoph Rochlitz
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Article
| Open AccessArtificial intelligence-based clustering and characterization of Parkinson's disease trajectories
- Colin Birkenbihl
- , Ashar Ahmad
- & Holger Fröhlich
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| Open AccessA proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes
- C. Dupire
- , P. Chennell
- & C. Morgat
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| Open AccessA validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract
- Phanit Songvut
- , Nanthanit Pholphana
- & Jutamaad Satayavivad
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| Open AccessPien Tze Huang regulates phosphorylation of metabolic enzymes in mice of hepatocellular carcinoma
- Jinxia Lin
- , Shicong Wang
- & Mei Li
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| Open AccessExtra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells
- Kirsten Bucher
- , Eduardo Rodríguez-Bocanegra
- & M. Dominik Fischer
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| Open AccessPredicting efficacy of drug-carrier nanoparticle designs for cancer treatment: a machine learning-based solution
- Md Raisul Kibria
- , Refo Ilmiya Akbar
- & Sepinoud Azimi
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| Open AccessMolecular docking, network pharmacology and experimental verification to explore the mechanism of Wulongzhiyangwan in the treatment of pruritus
- Lyu Anqi
- & Shan Shijun
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| Open AccessPreclinical evaluation of pentagamavunone-1 as monotherapy and combination therapy for pancreatic cancer in multiple xenograft models
- Naoki Kamitani
- , Ikuko Nakamae
- & Masayuki Sho
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| Open AccessAntimicrobial and anti-biofilm activity of Polygonum chinense L.aqueous extract against Staphylococcus aureus
- Jianye Zeng
- , Dandan Chen
- & Xiaomin Wang
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| Open AccessEffect of teriparatide on drug treatment of tuberculous spondylitis: an experimental study
- Subum Lee
- , Ye-Jin Seo
- & Dae-Chul Cho
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| Open AccessEffects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus
- Ryosuke Ono
- , Fumitaka Nishimae
- & Hiroyuki Mizuguchi
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| Open AccessEmergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis
- Frank Kloprogge
- , Julio Ortiz Canseco
- & Timothy D. McHugh
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| Open AccessImpact of SNPs, off-targets, and passive permeability on efficacy of BCL6 degrading drugs assigned by virtual screening and 3D-QSAR approach
- Solmaz Karimi
- , Farzaneh Shahabi
- & Saeed Khalili
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| Open AccessSuccinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning
- Sarah Piel
- , Joanna I. Janowska
- & Todd J. Kilbaugh
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| Open AccessAnticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification
- Kaori Soma
- , Kengo Watanabe
- & Masanori Izumi
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| Open AccessA robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria
- Sien Lequeue
- , Jessie Neuckermans
- & Joery De Kock
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| Open AccessChitosan oligosaccharide alleviates renal fibrosis through reducing oxidative stress damage and regulating TGF-β1/Smads pathway
- Jun Wu
- , Yingtao Xu
- & Yun Han
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| Open AccessSingle-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment
- Magda S. C. Fontes
- , Jasper Dingemanse
- & Patricia N. Sidharta