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METTL3 and METTL14-mediated N6-methyladenosine modification of SREBF2-AS1 facilitates hepatocellular carcinoma progression and sorafenib resistance through DNA demethylation of SREBF2
- Xianjian Wu
- , Min Zeng
- & Jian Pu
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Identification of a CpG-based signature coupled with gene expression as prognostic indicators for melanoma: a preliminary study
- Zhen Lin
- & Liu Yang
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Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients
- Saeedeh Hajebi Khaniki
- , Farhad Shokoohi
- & Mohammad Amin Kerachian
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Novel urine cell-free DNA methylation markers for hepatocellular carcinoma
- Selena Y. Lin
- , Wei Xia
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Systematic integration of m6A regulators and autophagy-related genes in combination with long non-coding RNAs predicts survival in glioblastoma multiforme
- Amit Sharma
- , Yulu Wang
- & Jarek Maciaczyk
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FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells
- Ai Asai-Nishishita
- , Masahiro Kawahara
- & Akira Andoh
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Article
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m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer
- Zhihua Chen
- , Quanfa Li
- & Shaoqin Chen
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Evaluation of epigenetic methylation biomarkers for the detection of colorectal cancer using droplet digital PCR
- J. Petit
- , G. Carroll
- & R. J. Scott
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Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality
- Ignacio Jusue-Torres
- , Richies Tiv
- & Alicia Hulbert
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FAT1 expression in T-cell acute lymphoblastic leukemia (T-ALL) modulates proliferation and WNT signaling
- Sven Liebig
- , Martin Neumann
- & Claudia D. Baldus
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Nutritional epigenomic and DNA-damage modulation effect of natural stilbenoids
- Sara Volpes
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Editorial
| Open AccessGuest Edited Collection: Epigenetics within the tumor microenvironment
The tumor microenvironment (TME) comprises of components that exist within the immediate vicinity of tumor cells, including fibroblasts, immune cells, the extracellular matrix, and more. Significant advances have been made in recent years in our understanding of the components of TME and their mutual interactions. Part of the focus of this research has been on epigenetic events, which are increasingly being recognized for their importance in gene regulation and cancer progression. The Collection represents the gradual growth in our understanding of the overall process of how cancer progresses, along with the factors that play a decisive role in this progression. It features studies conducted on models representing many different cancers, and includes mechanistic reports conducted using appropriate in vitro models, studies that analyzed human cancer patients-derived specimens, clinical trials and, additionally, studies involving bioinformatics, metabolomics, chemical libraries screening, next-generation sequencing, and single-cell analysis approaches.
- Aamir Ahmad
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RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer
- Yasuhiro Komatsu
- , Kunitoshi Shigeyasu
- & Toshiyoshi Fujiwara
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Article
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scTEM-seq: Single-cell analysis of transposable element methylation to link global epigenetic heterogeneity with transcriptional programs
- Kooper V. Hunt
- , Sean M. Burnard
- & Heather J. Lee
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Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
- Jiri Jungwirth
- , Marketa Urbanova
- & Veronika Vymetalkova
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Article
| Open Access
Application of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer
- Zhi Yao Ma
- , Cherry Sze Yan Chan
- & Wai K. Leung
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Article
| Open Access
Methylation profiling reveals novel molecular classes of rhabdomyosarcoma
- Michael R. Clay
- , Anand Patel
- & Brent A. Orr
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Article
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EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
- Yuko Kusakabe
- , Tetsuhiro Chiba
- & Naoya Kato
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Article
| Open Access
CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation
- Renan da Silva Santos
- , Daniel Pascoalino Pinheiro
- & Cristiana Libardi Miranda Furtado
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Article
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Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer
- Jean S. Fain
- , Axelle Loriot
- & Charles De Smet
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Article
| Open Access
A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
- Yang Liu
- , Qiuhong Wu
- & Jinming Yu
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Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors
- Seyoun Byun
- , Kajsa E. Affolter
- & Deborah W. Neklason
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Article
| Open Access
ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
- Yangming Hou
- , Yingjuan Xu
- & Dequan Wu
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Article
| Open Access
From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics
- T. J. M. Kuijpers
- , J. C. S. Kleinjans
- & D. G. J. Jennen
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Article
| Open Access
IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen
- Marta Libura
- , Emilia Bialopiotrowicz
- & Olga Haus
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Article
| Open Access
Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
- Helen Pasternack
- , Christiane Kuempers
- & Martin Reck
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Article
| Open Access
Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidates
- Gloria Bertoli
- , Claudia Cava
- & Isabella Castiglioni
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Article
| Open Access
Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer
- Mohamed K. Hassan
- , Amr A. Waly
- & Sherif F. El-khamisy
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Article
| Open Access
UBC9 coordinates inflammation affecting development of bladder cancer
- Xiaoliang Huang
- , Yuting Tao
- & Tianyu Li
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Article
| Open Access
Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice
- Robert J. Weeks
- , Jackie L. Ludgate
- & Ian M. Morison
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Article
| Open Access
Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy
- Satoshi Yamashita
- , Naoko Hattori
- & Hirofumi Mukai
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Article
| Open Access
Poor prognosis of NSCLC located in lower lobe is partly mediated by lower frequency of EGFR mutations
- Hyun Woo Lee
- , Young Sik Park
- & Chang-Hoon Lee
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Article
| Open Access
Update analysis on the association between Methionine synthase rs1805087 A/G variant and risk of prostate cancer
- Wei Zhang
- , Ze Zhang
- & Yun-Feng Shi
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Article
| Open Access
Anticancer properties of Tulbaghia violacea regulate the expression of p53-dependent mechanisms in cancer cell lines
- Lesetja R. Motadi
- , Mpho S. Choene
- & Nonkululeko N. Mthembu
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Article
| Open Access
Genome-wide DNA methylation analysis of KRAS mutant cell lines
- Ben Yi Tew
- , Joel K. Durand
- & Bodour Salhia
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| Open Access
Identification of candidate aberrantly methylated and differentially expressed genes in Esophageal squamous cell carcinoma
- Bao-Ai Han
- , Xiu-Ping Yang
- & Hai-Ying Sun
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Article
| Open Access
Bayesian Hyper-LASSO Classification for Feature Selection with Application to Endometrial Cancer RNA-seq Data
- Lai Jiang
- , Celia M. T. Greenwood
- & Longhai Li
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| Open Access
MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma
- Maryam Elahi
- & Vahid Rakhshan
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| Open Access
Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity
- Maxime Caron
- , Pascal St-Onge
- & Guillaume Bourque
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Article
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Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma
- Maria Giovanna Maturo
- , Sivaramakrishna Rachakonda
- & Rajiv Kumar
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Article
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HMGA1-pseudogene7 transgenic mice develop B cell lymphomas
- Marco De Martino
- , Davide De Biase
- & Francesco Esposito
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Article
| Open Access
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
- Beatriz Sánchez-Sendra
- , Eva Serna
- & Carlos Monteagudo
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Article
| Open Access
Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics
- Sadal Refae
- , Jocelyn Gal
- & Esma Saada-Bouzid
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Article
| Open Access
Crosstalk between DNA methylation and gene expression in colorectal cancer, a potential plasma biomarker for tracing this tumor
- Mohammad Amin Kerachian
- , Ali Javadmanesh
- & Kamran Ghaffarzadegan
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Article
| Open Access
Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors
- S. Greg Call
- , Ryan P. Duren
- & Orla M. Conneely
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Article
| Open Access
Comparative Clinicopathologic Characteristics and Outcomes of Paediatric and Adult Xp11 Translocation Renal Cell Carcinomas: a Retrospective Multicentre Study in China
- Wenliang Ma
- , Ning Liu
- & Weidong Gan
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Article
| Open Access
ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression
- Qingyang Ma
- , Kai Wu
- & Xiangyin Kong
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Article
| Open Access
Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response
- B. Niedermaier
- , A. Sak
- & M. Stuschke
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Article
| Open Access
Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- Hsing-Yu Yen
- , Chih-Wei Tsao
- & Chin-Yu Liu
Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers