Antibody fragment therapy articles within Scientific Reports

Featured

• Article
  30 December 2022 | Open Access

  Nanobodies targeting ABCC3 for immunotargeted applications in glioblastoma

  • Eduardo Ruiz-López
  • , Ivana Jovčevska
  •  & Alberto J. Schuhmacher

• Article
  04 August 2022 | Open Access

  Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein

  • Eero Hietanen
  • , Lav Tripathi
  •  & Petri Susi

• Article
  16 July 2022 | Open Access

  Development and characterization of a camelid derived antibody targeting a linear epitope in the hinge domain of human PCSK9 protein

  • Xinyang Li
  • , Jun Hong
  •  & Naibo Yang

• Article
  21 January 2022 | Open Access

  A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors

  • Julie K. Fierle
  • , Johan Abram-Saliba
  •  & Steven M. Dunn

• Article
  12 November 2021 | Open Access

  Computational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor

  • Wantanee Treewattanawong
  • , Thassanai Sitthiyotha
  •  & Surasak Chunsrivirot

• Article
  30 September 2021 | Open Access

  Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

  • Kevin J. Roberts
  • , Marion F. Cubitt
  •  & J. Scott Crowe

• Article
  01 April 2021 | Open Access

  Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo

  • Emanuel Peplau
  • , Francesco De Rose
  •  & Arne Skerra

• Article
  13 August 2020 | Open Access

  Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response

  • Mohammed M. Al Qaraghuli
  • , Karina Kubiak-Ossowska
  •  & Paul A. Mulheran

• Article
  17 October 2019 | Open Access

  Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

  • Javad Garousi
  • , Fokko J. Huizing
  •  & Vladimir Tolmachev

• Article
  06 September 2019 | Open Access

  Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery

  • Julie K. Fierle
  • , Johan Abram-Saliba
  •  & Steven M. Dunn

• Article
  02 August 2019 | Open Access

  A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51

  • Landon Pastushok
  • , Yongpeng Fu
  •  & C. Ronald Geyer

• Article
  29 January 2019 | Open Access

  A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations

  • Allison M. L. Nixon
  • , Alejandro Duque
  •  & Jason Moffat

• Article
  10 May 2018 | Open Access

  Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

  • Sofia Romano
  • , Vera Moura
  •  & João Gonçalves

• Article
  03 April 2018 | Open Access

  Affinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method

  • Hideaki Sanada
  • , Kazuki Kobayashi
  •  & Izumi Kumagai

• Article
  20 December 2017 | Open Access

  The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent

  • Christopher Bachran
  • , Matthias Schröder
  •  & Lee Kim Swee

• Article
  20 November 2017 | Open Access

  Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells

  • Michael Zorniak
  • , Paul A. Clark
  •  & John S. Kuo

• Article
  20 October 2017 | Open Access

  TNFR1 inhibition with a Nanobody protects against EAE development in mice

  • Sophie Steeland
  • , Sara Van Ryckeghem
  •  & Claude Libert

• Article
  19 July 2017 | Open Access

  Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities

  • Naoya Shinozaki
  • , Ryuji Hashimoto
  •  & Susumu Uchiyama

• Article
  06 June 2017 | Open Access

  A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity

  • Aruto Sugiyama
  • , Mitsuo Umetsu
  •  & Izumi Kumagai

• Article
  27 January 2017 | Open Access

  Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

  • Xiaofeng Liu
  • , Richard D. Taylor
  •  & Terry Baker

• Article
  10 July 2015 | Open Access

  A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments

  • Nisha Nanaware-Kharade
  • , Shraddha Thakkar
  •  & Eric C. Peterson

• Article
  17 December 2014 | Open Access

  Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

  • Filippa Fleetwood
  • , Susanne Klint
  •  & John Löfblom

• Article
  14 January 2014 | Open Access

  Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering

  • Shraddha Thakkar
  • , Nisha Nanaware-Kharade
  •  & Kottayil I. Varughese