Optimization of energy and carbon–nitrogen allocation maximizes the proliferation and functionality of chimeric antigen receptor (CAR)-T cells. Lakhani et al. report that tonic signalling elements (scFvs) affect CAR-T cell metabolic fitness in an antigen-independent manner. A modest carbon–nitrogen emission (overflow) and resilient metabolic phenotype (compatibility) are associated with effective CAR-T cell therapy.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gnanaprakasam, J. N. R. et al. Nat. Metab. 5, 1423–1439 (2023).
Zhao, Y. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02060-8 (2024).
Li, W. et al. Immunity 53, 456–470.e6 (2020).
Kawalekar, O. U. et al. Immunity 44, 380–390 (2016).
Lakhani, A. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01034-7 (2024).
Bell, H. N. et al. Cell Metab. 35, 134–149.e6 (2023).
Frigault, M. J. et al. Cancer Immunol. Res. 3, 356–367 (2015).
Long, A. H. et al. Nat. Med. 21, 581–590 (2015).
Chen, J. et al. Cell Res. 33, 341–354 (2023).
Watanabe, N. et al. OncoImmunology 5, e1253656 (2016).
Qiu, S. et al. Cell Res. https://doi.org/10.1038/s41422-024-00936-1 (2024).
Chen, X., Liu, L., Kang, S., Gnanaprakasam, J. R. & Wang, R. Sci. Adv. 9, eadd9554 (2023).
Wang, H., Song, X., Shen, L., Wang, X. & Xu, C. Trends Cancer 8, 123–134 (2022).
Wang, H., Huang, Y. & Xu, C. Immunol. Rev. 320, 138–146 (2023).
Chen, X. et al. Cancer Immunol. Res. 11, 150–163 (2023).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wang, H., Huang, Y. & Wang, R. Tonic-ing emissions and compatibility to turbocharge CAR-T. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01022-x
Published:
DOI: https://doi.org/10.1038/s42255-024-01022-x