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Depression refers to a state of low mood that can be accompanied with loss of interest in activities that the individual normally perceived as pleasurable, altered appetite and sleep/wake balance. Its severe form, major depression is classified as a mood disorder.
Wastewater analysis can quantify the pharmaceuticals used to treat mental health disorders, providing data for policy development. This Comment highlights the potential of such wastewater-based epidemiology to enhance the estimation of treated mental health disorders at the community level.
Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.