Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunotherapy

A milestone method to make natural killer T cells

A differentiation protocol to produce off-the-shelf natural killer T cells may enable clinical application.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: AlloCAR-NKT cells derived from hematopoietic stem and progenitor cells target tumor cells and tumor-supportive myeloid cells.

References

  1. Li, Y.-R. et al. Nat. Biotechnol., https://doi.org/10.1038/s41587-024-02226-y (2024).

  2. Bendelac, A., Savage, P. B. & Teyton, L. Annu. Rev. Immunol. 25, 297–336 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Song, L. et al. J. Clin. Invest. 119, 1524–1536 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Smyth, M. J. et al. Blood 99, 1259–1266 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Shimizu, K., Kurosawa, Y., Taniguchi, M., Steinman, R. M. & Fujii, S. J. Exp. Med. 204, 2641–2653 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Heczey, A. et al. Nat. Med. 29, 1379–1388 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. de Lalla, C. et al. J. Immunol. 186, 4490–4499 (2011).

    Article  PubMed  Google Scholar 

  8. Ramos, C. A. et al. Transplant. Cell. Ther. 30, S41–S42 (2024).

    Article  Google Scholar 

  9. Yamada, D. et al. Stem Cells 34, 2852–2860 (2016).

    Article  CAS  PubMed  Google Scholar 

  10. Li, Y. R. et al. Cell Rep. Med. 2, 100449 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leonid S. Metelitsa.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Metelitsa, L.S. A milestone method to make natural killer T cells. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02243-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41587-024-02243-x

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer