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| Open AccessTranscriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region
- Hernan A. Bazan
- , Surjyadipta Bhattacharjee
- & Nicolas G. Bazan
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| Open AccessVinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways
- Zeena A. Hussein
- , Ahmed R. Abu-Raghif
- & Hayder Adnan Fawzi
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| Open AccessJnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen
- Ye Hong
- , Christel Sourander
- & Eleanor Coffey
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| Open AccessChemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine
- Yang Sun
- , Sofia Rodríguez-Rangel
- & Pedro Brugarolas
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| Open AccessMiR-21-5p modulates LPS-induced acute injury in alveolar epithelial cells by targeting SLC16A10
- Huanan Zeng
- , Yuqing Zhou
- & Wei Liu
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| Open AccessMultifunctional in vitro, in silico and DFT analyses on antimicrobial BagremycinA biosynthesized by Micromonospora chokoriensis CR3 from Hieracium canadense
- Rabia Tanvir
- , Saadia Ijaz
- & Shahida Hasnain
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| Open AccessTopical insulin in neurotrophic keratopathy after diabetic vitrectomy
- Taher K. Eleiwa
- , Ahmed A. Khater
- & Abdelrahman M. Elhusseiny
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| Open AccessAnti-inflammatory properties and characterization of water extracts obtained from Callicarpa kwangtungensis Chun using in vitro and in vivo rat models
- Jun-Jian Li
- , Li Li
- & Jian-Xin Liu
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| Open AccessA simple and highly sensitive LC–MS workflow for characterization and quantification of ADC cleavable payloads
- Shi Ya Mak
- , Shuwen Chen
- & Ying Swan Ho
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| Open AccessEfficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research
- Yanran Tong
- , Yukiko Ueyama-Toba
- & Hiroyuki Mizuguchi
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| Open AccessIn vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
- Linyue Shang
- , Huimei Wei
- & Fang Zheng
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| Open AccessExploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis
- Muhammad Fayaz Khan
- , Amjad Ali
- & Abdul Jabbar
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| Open AccessPradimicin U, a promising antimicrobial agent isolated from a newly found Nonomuraea composti sp. nov
- Thitikorn Duangupama
- , Pattama Pittayakhajonwut
- & Chitti Thawai
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| Open AccessAdvancing molecular modeling and reverse vaccinology in broad-spectrum yellow fever virus vaccine development
- Ohana Leticia Tavares da Silva
- , Maria Karolaynne da Silva
- & Jonas Ivan Nobre Oliveira
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| Open AccessIn-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells
- Sean N. Avedissian
- , Johid R. Malik
- & Courtney V. Fletcher
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| Open AccessBaicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis
- Lihua Shao
- , Li Zhu
- & Hailong Li
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| Open AccessEmerging opportunities of using large language models for translation between drug molecules and indications
- David Oniani
- , Jordan Hilsman
- & Yanshan Wang
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| Open AccessSilver and gold nanoparticles as a novel approach to fight Sarcoptic mange in rabbits
- Eman I. Hassanen
- , Eman A. Morsy
- & Mohamed Shaalan
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| Open AccessPreparation of orodispersible tablets of bosentan using xylitol and menthol as dissolution enhancers
- Rania Mohamed Sakr
- , Abdelaziz El Sayed Abdelaziz
- & Gamal Mohamed El Maghraby
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| Open AccessDevelopment of a new affinity maturation protocol for the construction of an internalizing anti-nucleolin antibody library
- Rita Ribeiro
- , João N. Moreira
- & João Goncalves
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| Open AccessEvaluation of the immune system status and hematological dyscrasias, among amphetamine and cannabis abusers at Eradah Hospital in Qassim, Saudi Arabia
- Amal Hussain Mohammed
- , Atheer Saleh Aljarallah
- & Afshan Zeeshan Wasti
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| Open AccessEnhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery
- Remya Radha
- , Vinod Paul
- & Ghaleb A. Husseini
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| Open AccessAntioxidant and anti-inflammatory function of Eupatorium adenophora Spreng leaves (EASL) on human intestinal Caco-2 cells treated with tert-butyl hydroperoxide
- Li Zheng-qiang
- , Ni Jun
- & Yang Xiao-yan
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| Open AccessMass spectrometric analysis of Odonthobuthus Doriae scorpion venom and its non-neutralized fractions after interaction with commercial antivenom
- Adel Abdollahnia
- , Kiumars Bahmani
- & Alireza Ghassempour
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| Open AccessSynthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (Mpro)
- Deepika Geedkar
- , Ashok Kumar
- & Pratibha Sharma
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| Open AccessA Japanese herbal medicine (kampo), hochuekkito (TJ-41), has anti-inflammatory effects on the chronic obstructive pulmonary disease mouse model
- Masaaki Yuki
- , Taro Ishimori
- & Akihisa Mitani
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| Open AccessEnhancing tuberculosis vaccine development: a deconvolution neural network approach for multi-epitope prediction
- Auwalu Saleh Mubarak
- , Zubaida Said Ameen
- & Dilber Uzun Ozsahin
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| Open AccessAn Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection
- Komal Beeton
- , Dipanwita Mitra
- & Ritesh Tandon
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| Open AccessAutocorrelation analysis of a phenotypic screen reveals hidden drug activity
- Richard A. Dubach
- & J. Matthew Dubach
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| Open AccessOn the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
- Xixi Wang
- , Yanfei Wang
- & Yalian Sa
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| Open AccessExploration of the photothermal role of curcumin-loaded targeted carbon nanotubes as a potential therapy for melanoma cancer
- Bahareh Kargar
- , Mehdi Fazeli
- & Amin Reza Akbarizadeh
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| Open AccessPreparation and characterization of artemether-loaded niosomes in Leishmania major-induced cutaneous leishmaniasis
- Uranous Niroumand
- , Mohammad Hossein Motazedian
- & Soliman Mohammadi-Samani
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| Open AccessAn eco-friendly and cost-effective HPTLC method for quantification of COVID-19 antiviral drug and co-administered medications in spiked human plasma
- Ekram A. Ghozzy
- , Nahed M. El-Enany
- & Samah Abo El Abass
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| Open AccessPorphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents
- Debdulal Sharma
- , Aradhana Singh
- & Devashish Sengupta
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| Open AccessInjectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles for tumor postoperative treatments and wound repair
- Qiang Zhang
- , Yu Zhang
- & Zhen-Fa Zhang
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| Open AccessCheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2
- Jobin Thomas
- , Anupam Ghosh
- & Jitendra Satija
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| Open AccessPreclinical evaluation of novel synthesised nanoparticles based on tyrosine poly(ester amide) for improved targeted pulmonary delivery
- Eman Zmaily Dahmash
- , Nour Radwan Achkar
- & Hamad Alyami
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| Open AccessEnhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii
- Nalumon Thadtapong
- , Soraya Chaturongakul
- & Sunhapas Soodvilai
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| Open AccessIdentification of PANoptosis-related biomarkers and analysis of prognostic values in head and neck squamous cell carcinoma
- Ping Yang
- , Guangzhao Huang
- & Qian Li
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| Open AccessSGLT2i impact on HCC incidence in patients with fatty liver disease and diabetes: a nation-wide cohort study in South Korea
- Hyo Jung Cho
- , Eunyoung Lee
- & Jae Youn Cheong
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| Open AccessLigand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
- Md. Rezaul Islam
- , Md. Shafiqul Islam Sovon
- & Gezahign Fentahun Wondmie
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| Open AccessSphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies
- Shinsuke Nakamura
- , Rie Yamamoto
- & Hideaki Hara
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| Open AccessGenetic polymorphisms and clinical parameters associated with renal toxicity in Thai hematologic malignancy patients receiving high dose methotrexate
- Palada Pitakkitnukun
- , Thanakit Pongpitakmetha
- & Chantana Polprasert
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| Open AccessQuality control in SARS-CoV-2 RBD-Fc vaccine production using LC–MS to confirm strain selection and detect contaminations from other strains
- Pipob Suwanchaikasem
- , Kaewta Rattanapisit
- & Waranyoo Phoolcharoen
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| Open AccessAnti-inflammatory and anti-diabetic properties of indanone derivative isolated from Fernandoa adenophylla in vitro and in silico studies
- Abdur Rauf
- , Umer Rashid
- & Dorota Formanowicz
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| Open AccessAgonist-selective activation of individual G-proteins by muscarinic receptors
- Dominik Nelic
- , Nikolai Chetverikov
- & Alena Janoušková-Randáková
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Article
| Open AccessApigenin and its combination with Vorinostat induces apoptotic-mediated cell death in TNBC by modulating the epigenetic and apoptotic regulators and related miRNAs
- Snehal Nimal
- , Navanath Kumbhar
- & Rajesh N. Gacche
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| Open AccessSynthesis and molecular docking studies of new aryl imeglimin derivatives as a potent antidiabetic agent in a diabetic zebrafish model
- Aylin Khodakhah
- , Hassan Mohammadi
- & Massoud Amanlou
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| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq